What is semi-conservative replication of DNA? And why is it important?

Semi-conservative DNA replication involves splitting open the parent cells DNA duplex and exposing both strands. Now these strands are accessible to replication machinery to act as a template, so that the sequence can be 'read' and a daughter strand synthesised that is complementary to each parent strand. This will produce two DNA duplexes which have one parent strand and one daughter strand. The semi-conservative mechanism minimises errors in DNA replication, because the template gives DNA polymerase something accurate to copy from. This is very important because cells want to minimise errors in replication when dividing, so that mutations (such as incorrect bases, deletions, insertions) are not brought into the genome. Mutations in genes can cause proteins to become non-functional and lead to disease, including cancer.

KP

Related Biology A Level answers

All answers ▸

Compare and contrast the structures and starch and cellulose and explain how these relate to their functions in the cell


Glycogen and amylose are used for energy storage. Glycogen is found in animals. Amylose is found in plants. Describe how the structure of glycogen allows it to perform its function and explain the advantage to animals of using glycogen as an energy


Why do insulin levels rise in the body following a meal, and what effects does the insulin have?


Describe the structure of the blastocyst