Outline the Stages of Mitosis
Pre-Mitosis:
Interphase:
- DNA as uncondensed chromatin
- DNA contained within nucleus
- Centrosomes etc duplicated
- Cell enlarged
Stages of Mitosis
Prophase:
- DNA Supercoils & chromosomes condense
- Chromosomes comprised of chromatics
- Paired centrosomes move to opposite poles of the cell & form microtubule spindle fibres
- Nuclear membrane breaks down, nuckeus dissolves
Metaphase
- Microtubules connect to chromosome centromeres
- Microtubule depolymerisation = shortening and contraction of spindle fibres
- Chromosomes align with cell centre
Anaphase
- Contraction of spinde fibres continues - sister chromatids separate
- Chromosomes move to opposite poles
Telophase
- On arrival of chromosomes at poles, spindle fibres dissolve
- Chromosomes decondense
- Nuclear membrane reforms
- Cytokinesis occurs, dividing the cell
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