Explain how a substitution mutation could cause an enzyme not to work (5)

The mutation changes the order of bases so there is a different triplet code present. This results in a different amino acid being coded for in the polypeptide chain. This means a different protein with a different tertiary structure is made. The enzymes active site will also be different and no longer complimentary to the substrate. Therefore no reaction can make place as the substrate can not fit into the enzymes active site any more.

EC
Answered by Evie C. Biology tutor

7302 Views

See similar Biology GCSE tutors

Related Biology GCSE answers

All answers ▸

A large amount of sewage enters a river and many of the fish die. Sewage contains bacteria and organic material. Explain why the fish died.


Compare the advantages and disadvantages of light and electron microscopes.


Explain how hydrogen bonding occurs between molecules of water.


Describe how deforestation is causing the change in the amounts of different gasses in the atmosphere


We're here to help

contact us iconContact ustelephone icon+44 (0) 203 773 6020
Facebook logoInstagram logoLinkedIn logo

MyTutor is part of the IXL family of brands:

© 2025 by IXL Learning