What causes bacteria to become antibiotic resistant?

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Mutations, which is a change in the base code of DNA, occur regularly and can have various affects on organisms. Some mutations may give the bacteria an advantage against an antibiotic, for example if the target site for the antibiotic was altered then the antibiotic may be less able to bind, so has less of an effect on the bacteria. This means the bacteria with this mutation have an advantage and natural selection occurs when an antibiotic is applied to the culture of bacteria so that the resistant bacteria survive and therefore can reproduce with less competition and pass on their antibiotic resistant mutation. 

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