I have fairly broad subject interests, and a particular interest in the core subjects- Maths, Science and English- lead me to pursue these at A-level. However, it is the sciences that I am naturally inclined to and have a passion for. I have tutored in various settings and worked with students ranging from 8 to 18, starting off with friends and family, then going on work at my own sixth form and high school where I tutored A-level and GCSE Science. I have learnt a lot from my previous experiences, including tailoring my approach to a specific individual and adapting my teaching to ensure that it is effective for them as a unique learner. I am able to offer creative and personalised methods of approaching problem areas, and am also very familiar with the science courses in particular, being aware of areas that students commonly struggle with, common mistakes that are made and knowing what level of knowledge and skill is required to be attain target grades.
What I aim for:
I aim to help students advance as far forward in terms of their subject knowledge and exam technique so that they can attain the best grades possible. I aim to help students to develop a broader view of their subject, its place ‘in the real world’, its relevance and important concepts and principles that puts the course material into context and helps it make more sense. I believe in first developing a clear understanding of basic ideas and skills, and, where possible, I try to help each student develop their approach to learning and foster critical and logical thinking that will help them in their future studies.
What will the sessions include?
Whatever you want to work on! Once I familiarise myself with your goals and your general abilities, I will work with you to identify other areas that need work and we’ll make a realistic plan of what we can do in the allotted time. There is no rigidity in the process, and we can always change emphasis or slow down and take up a new approach depending on what works for you. In the session, we will use various ways of learning content and engage in some active ways of honing in on and applying this. Exam practice will be brought in where appropriate.
How can I get started?
If you would like my help, send me a webmail or book a free Meet the Tutor session, both of which can be done on this website. You can make a decision once we have met- there’s no rush!
I look forward to meeting you!
|Biology||A Level||£24 /hr|
|Chemistry||A Level||£24 /hr|
Darren (Parent) October 5 2016
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Darren (Parent) May 21 2016
In order to understand cross bridge cycling and its importance in muscle contraction, you need to be familiar with the ‘contractile machinery’ that causes muscle contraction and the sliding filament theory. To briefly recap, muscle contraction occurs when the thin filament, actin, slides past the thick filament, myosin - This is essentially the sliding filament theory. The mechanism that causes the actin filaments to slide past myosin in skeletal muscle in brief is as follows:
remembering that a sarcomere is the stretch of myofibril between two z lines where myosin in central and an actin filament is both above and below the myofibril on each side of it, with its medial side slightly overlapping myosin and its lateral side attached firmly to the z line .
Nerve impulse arrives at muscle, causing release of calcium from the sarcoplasmic reticulum of muscle fibre
Troponin is bound to tropomyosin which is bound to actin. When the muscle is at rest, tropomyosin is sitting in such a position, that it is covering the binding sites for myosin heads on actin.
Calcium bind to troponin. This causes it to undergo a conformational change which pulls the tropomyosin it is attached to out of its resting position, exposing binding sites for myosin heads on actin.
Myosin heads covalently bind to the exposed binding sites.
The myosin head undergoes a conformational change which pulls the actin along.
It then releases the actin, returns to its original conformation, extending out laterally again and forms a bind with another actin binding site that is further along the actin and closer to the z line. This repeated motion is what causes the sliding of the actin filament past myosin.
Cross bridge cycling refers specifically to the action of the cross bridge, that being the head and hinge region of the myosin filament. It is essentially acting like a bridge when the head is covalently bonded to actin, and this bridge is continuously being formed and broken during muscle contraction-the cross bridges are being cycled, and it is this action which is allowing for the filaments to slide the way they do.
The cross bridge cycle can be broken down as follows:
Hydrolysis of ATP to ADP and Pi, with products still covalently bonded to myosin, cause it to enter an energised state.
Cross bridge binds to actin. It undergoes a conformational change. ADP and Pi are released. You then get a power stroke (ie cross bridge moves, pulling actin along which causes the power stroke (ie the cross bridge moves pulling the actin along)
ATP binds to myosin, causing cross bridge to detach.
The process starts again.see more