What is the 'lagging strand' in DNA replication, and how is it different from the 'leading strand'?

The lagging strand in DNA replication is the strand of the double-stranded DNA molecule that has to be synthesised discontinuously. This is because the two strands of DNA molecules are antiparallel, so run in opposite directions. DNA polymerase can only polymerise DNA nucleotides in a 5' to 3' direction, so can only use a template strand that runs in a 3' to 5' direction. The DNA strand that runs in this direction is synthesised continuously, but the other DNA strand must be synthesised in Okazaki fragments joined with the help of DNA ligase and DNA polymerase 1 (in prokaryotes).

GR
Answered by George R. Biology tutor

11090 Views

See similar Biology IB tutors

Related Biology IB answers

All answers ▸

What are the similarities and differences between mitosis and meiosis?


Do you have any exam tips for Biology Paper 2?


I know all the theory, but I can never score well with the essay questions in paper 2. Why?


Discuss the differences between DNA and RNA. (4 pts)


We're here to help

contact us iconContact ustelephone icon+44 (0) 203 773 6020
Facebook logoInstagram logoLinkedIn logo

MyTutor is part of the IXL family of brands:

© 2026 by IXL Learning