What is the 'lagging strand' in DNA replication, and how is it different from the 'leading strand'?

The lagging strand in DNA replication is the strand of the double-stranded DNA molecule that has to be synthesised discontinuously. This is because the two strands of DNA molecules are antiparallel, so run in opposite directions. DNA polymerase can only polymerise DNA nucleotides in a 5' to 3' direction, so can only use a template strand that runs in a 3' to 5' direction. The DNA strand that runs in this direction is synthesised continuously, but the other DNA strand must be synthesised in Okazaki fragments joined with the help of DNA ligase and DNA polymerase 1 (in prokaryotes).

GR
Answered by George R. Biology tutor

9533 Views

See similar Biology IB tutors

Related Biology IB answers

All answers ▸

How does cell division occur?


Explain how the properties of water are significant to living organisms.


What type of cells do multipotent stem cells go on to form?


What techniques were employed in the 'Calvin Experiment' to elucidate the carboxylation of RuBP (IB-HL 8.3)?


We're here to help

contact us iconContact ustelephone icon+44 (0) 203 773 6020
Facebook logoInstagram logoLinkedIn logo

MyTutor is part of the IXL family of brands:

© 2025 by IXL Learning