How could ionic interactions be used in DNA-RNA hybridisation?

The DNA double helix consists of many hydrogen bonds between the base pairs, but in addition there are negatively charged phosphate molecules as a key component of the sugar-phosphate backbone of DNA strands. In order to induce the hybridisation between a single stranded DNA molecule and a complementary single RNA strand, the double helix must be separated. This is done by introducing ions such as Na+ and Mg2+; as these are positively charged ions, they will interact and partially counteract the phosphates negative charge. Having these ions present in a water solution, will also allow the hydrogen bonds between the bases to be temporarily relocated to having formed hydrogen bonds with the water solution.

MA
Answered by Mohammed A. Biology tutor

1674 Views

See similar Biology University tutors

Related Biology University answers

All answers ▸

Describe the process of ventilation in humans. (4 marks)


What benefits does compartmentalisation confer on cells?


Explain the need for neuronal communication over chemical signalling or passive electrical signalling


done


We're here to help

contact us iconContact ustelephone icon+44 (0) 203 773 6020
Facebook logoInstagram logoLinkedIn logo

MyTutor is part of the IXL family of brands:

© 2026 by IXL Learning