MYTUTOR SUBJECT ANSWERS

483 views

What is Cystic Fibrosis? Explain the mechanism behind this disease.

Cystic fibrosis (CF) is an autosomal recessive genetic condition most commonly caused by the deltaF508 mutation in the CFTR (Cystic Fibrosis Transmembrane Regulator) gene. This disease is characterised by difficulty breathing, recurrent lung infections and problems with pancreatic function (pancreatic insufficiency).

The CFTR gene encodes an ATP gated plasma membrane chloride channel expressed in the cells lining the sweat gland, lungs, pancreas and other glands in the body. In healthy individuals this chloride channel transports chloride ions out of cells lining these glands into the inside of the gland. This draws water molecules into the gland. In individuals with CF, mutations to CFTR lead to the production of non-functioning channels, or the absence of CFTR channels.

In CF, the absence of these chloride ions leads to a reduction in the amount of water that passes into the gland. The most notable consequence of this is an increased viscosity (thickness) of the mucus produced in the lungs. This thicker mucus is harder for the cilia in the lungs to clear and increases the risk of infection. This is why individuals with CF have recurrent lung infections and difficulties breathing.

Pancreatic issues in CF are the result of blockage of the pancreatic ducts by the thickened mucus, leading to damage by accumulated digestive enzymes.

Jonathan B. A Level Biology tutor, GCSE Biology tutor, A Level Chemis...

11 months ago

Answered by Jonathan, who tutored Mentoring -Medical School Preparation- with MyTutor


Still stuck? Get one-to-one help from a personally interviewed subject specialist

98 SUBJECT SPECIALISTS

£20 /hr

Anum H.

Degree: Biochemistry (Bachelors) - Birmingham University

Subjects offered:-Medical School Preparation-, Science+ 4 more

-Medical School Preparation-
Science
Maths
Extended Project Qualification
Biology
-Personal Statements-

“1st year Biochemistry student. Science and technology editor for Redbrick newspaper. Tutoring since 2014.”

MyTutor guarantee

£20 /hr

Gayathri S.

Degree: Medicine (Bachelors) - Birmingham University

Subjects offered:-Medical School Preparation-, Maths+ 3 more

-Medical School Preparation-
Maths
Biology
.UKCAT.
-Personal Statements-

“I’m a medical student keen to pass on my passion for learning to others! I’m immediately available to tutor at flexible times.”

£22 /hr

Naomi S.

Degree: Medicine (Bachelors) - Trinity College Dublin University

Subjects offered:-Medical School Preparation-, Music+ 4 more

-Medical School Preparation-
Music
Maths
Human Biology
Chemistry

“*Available to teach exam revision sessions immediately.* I'm a medical student at Trinity College Dublin. ”

About the author

Jonathan B.

Currently unavailable: for new students

Degree: Medicine (With a BA in Pharmacology) (Other) - Cambridge University

Subjects offered:-Medical School Preparation-, Chemistry+ 4 more

-Medical School Preparation-
Chemistry
Biology
.BMAT (BioMedical Admissions)
-Personal Statements-
-Oxbridge Preparation-

“Me I am a Medical Student at the University of Cambridge. I am friendly, patient and have always had apassion for teaching others. I also love to understand everything, no matter what the subject, and believe that understanding is the...”

You may also like...

Other Mentoring -Medical School Preparation- questions

Are extra-curricular activities important to write about on your personal statement?

What sort of work experience should I be trying to get and how much is appropriate?

How can I make the most of my work experience?

How does the blood resist change in PH?

View Mentoring -Medical School Preparation- tutors

We use cookies to improve your site experience. By continuing to use this website, we'll assume that you're OK with this. Dismiss

mtw:mercury1:status:ok