MYTUTOR SUBJECT ANSWERS

257 views

What is Cystic Fibrosis? Explain the mechanism behind this disease.

Cystic fibrosis (CF) is an autosomal recessive genetic condition most commonly caused by the deltaF508 mutation in the CFTR (Cystic Fibrosis Transmembrane Regulator) gene. This disease is characterised by difficulty breathing, recurrent lung infections and problems with pancreatic function (pancreatic insufficiency).

The CFTR gene encodes an ATP gated plasma membrane chloride channel expressed in the cells lining the sweat gland, lungs, pancreas and other glands in the body. In healthy individuals this chloride channel transports chloride ions out of cells lining these glands into the inside of the gland. This draws water molecules into the gland. In individuals with CF, mutations to CFTR lead to the production of non-functioning channels, or the absence of CFTR channels.

In CF, the absence of these chloride ions leads to a reduction in the amount of water that passes into the gland. The most notable consequence of this is an increased viscosity (thickness) of the mucus produced in the lungs. This thicker mucus is harder for the cilia in the lungs to clear and increases the risk of infection. This is why individuals with CF have recurrent lung infections and difficulties breathing.

Pancreatic issues in CF are the result of blockage of the pancreatic ducts by the thickened mucus, leading to damage by accumulated digestive enzymes.

Jonathan B. A Level Biology tutor, GCSE Biology tutor, A Level Chemis...

7 months ago

Answered by Jonathan, who tutored Mentoring -Medical School Preparation- with MyTutor


Still stuck? Get one-to-one help from a personally interviewed subject specialist

56 SUBJECT SPECIALISTS

£22 /hr

Ellen C.

Degree: Medicine (Bachelors) - Cardiff University

Subjects offered: -Medical School Preparation-, Maths+ 5 more

-Medical School Preparation-
Maths
Extended Project Qualification
Chemistry
Biology
.UKCAT.
-Personal Statements-

“I am passionate about getting to know students to maximise their full potential. I like to take the time to really get to know each student to understand how they work best, revision techniques that suit them and ways in which I can s...”

£30 /hr

Subi S.

Degree: Medicine (Bachelors) - Cambridge University

Subjects offered: -Medical School Preparation-, Chemistry+ 5 more

-Medical School Preparation-
Chemistry
Biology
.UKCAT.
.BMAT (BioMedical Admissions)
-Personal Statements-
-Oxbridge Preparation-

“I am a medical student currently studying at Cambridge University. I have always loved Biology and enjoy teaching it! I think that science should be studied in a practical way with pictures and models and experiments - textbooks too! ...”

£20 /hr

Giovana K.

Degree: Clinical Medicine (Other) - Edinburgh University

Subjects offered: -Medical School Preparation-, Psychology+ 1 more

-Medical School Preparation-
Psychology
Human Biology

“About me: Hello! My name is Giovana and I am fourth year medical student. I have completed my pre-clinical studies at the University of Cambridge and now I am at my clinical years at the University of Edinburgh. I have always been f...”

About the author

Jonathan B.

Currently unavailable: for new students

Degree: Medicine (With a BA in Pharmacology) (Other) - Cambridge University

Subjects offered: -Medical School Preparation-, Chemistry+ 4 more

-Medical School Preparation-
Chemistry
Biology
.BMAT (BioMedical Admissions)
-Personal Statements-
-Oxbridge Preparation-

“Me I am a Medical Student at the University of Cambridge. I am friendly, patient and have always had apassion for teaching others. I also love to understand everything, no matter what the subject, and believe that understanding is the...”

You may also like...

Other Mentoring -Medical School Preparation- questions

Which university should I apply to, Cambridge or Oxford?

How much reading should I aim to do before attending a medical school interview?

Where should I apply to medical school?

How do I tackle interview questions that ask me for an example where I showed a particular skill?

View Mentoring -Medical School Preparation- tutors

Cookies:

We use cookies to improve our service. By continuing to use this website, we'll assume that you're OK with this. Dismiss

mtw:mercury1:status:ok