How does Acetylcholine act on a neuronal synapse, and how is it re-uptaken?

 - Ca2+ voltage gated channels are activated due to an action potential reaching the synapse

 - Acetylcholine rests in the pre-synaptic cleft

 - They are stored in vesicles

 - The calcium influx causes the vesicles to move and fuse with the pre-synaptic membrane

 - They release their contents (Ach) into the synaptic cleft through diffustion through a channel

 - Ach binds to neuroreceptors on the post synaptic cleft, causing the channels to open and depolarisation to occur in the postsynaptic cleft

 - Excess Ach in the synaptic cleft is broken down by acetylcholinesterase to form Acetate & Choline

 - Choline is transported back into the axon terminal and is used to produce more Ach in the presynaptic neurone.