How is an action potential generated?

Firstly the resting membrane is set by Na+/K+ ATPase so that 3 Na+ moves out for every 2K+ that moves in; this creates a negative membrane potential of around -65mV. To initiate an action potential the membrane must depolarise to the threshold value. When the threshold value is reached Na+ channels open, allowing a rapid inflow of Na+ ions making the membrane potential more positive (around +40mV). At this point Na+ channels begin to close as K+ channels open, meaning that K+ ions move out of the cell making the membrane potential more negative. The membrane hyperpolarises (goes below the resting membrane potential) because the K+ channels are slow to close meaning more K+ ions move out. The neuron goes through a refractory period to equilibrate ions across the membrane and allow another action potential can be fired. 

KB
Answered by Kate B. Biology tutor

4228 Views

See similar Biology A Level tutors

Related Biology A Level answers

All answers ▸

Name two features of plant cells that are not features of animal cells


Describe the process of transcription for a gene


How does MRI work?


Describe how the rhythmicity of the heart is established and maintained with respect to the different stages in the cardiac cycle (6 marks)


We're here to help

contact us iconContact ustelephone icon+44 (0) 203 773 6020
Facebook logoInstagram logoLinkedIn logo

MyTutor is part of the IXL family of brands:

© 2025 by IXL Learning