Why is the resting membrane potential of a neurone negative when there are positive ions inside the cell?

The resting membrane potential inside the neurone (-70mV) is negative relative the outside! This means that even though there are both Na+ and K+ ions inside the cell, there are fewer of them (-70mV fewer) inside the cell compared to the outside. There are also more negative ions, e.g. Cl-, inside the cell compared to outside. The 'membrane potential' (charge) inside the neurone is less than that outside of the neurone, and therefore negative. In summary, the resting membrane potential is negative due to the amounts (concentration) of positive and negative ions inside/outside of the cell, not the charge of the ions themselves.

CS
Answered by Chloe S. Biology tutor

3829 Views

See similar Biology A Level tutors

Related Biology A Level answers

All answers ▸

What is osmosis?


What is the founder effect? How can it influence the genetic profile of a population?


How would you structure and answer the essay section of the exam?


a) Explain how an action potential is passed across a synapse b) Label the graph below with the steps of action potential generation c) The graph shows the results of a study on two groups taking different medication, is the difference significant?


We're here to help

contact us iconContact ustelephone icon+44 (0) 203 773 6020
Facebook logoInstagram logoLinkedIn logo

MyTutor is part of the IXL family of brands:

© 2025 by IXL Learning