How does base deletion in the DNA code produce a nonfunctional protein?

Base deletion leads to a frame shift error as the DNA code is read in triplet codons and is non overlapping. This leads to different amino acids being translated and a different primary structure. This leads to different hydrogen bonds forming and so a different secondary structure. This leads to different disulfide bridges and hydrophobic interactions forming and affecting the overall tertiary structure of the active site. Substrate cannot fit leading to no ES complex formed and no catalysis of a reaction.