How does a stimulus produce an action potential?

The cell begins at a resting potential of -85mV with a high concentration of potassium (K+) inside the cell. The stimulus must be strong enough to produce the all or nothing response which triggers the opening of the voltage-gated sodium (Na+) channels. This allows Na+ ions to flood into the cell. This is known as depolarization and the cell potential difference is now at +30mV. The next stage is repolarization in which the Na+ channels close and the K+ channels open. Due to the laws of diffusion, K+ moves from a higher concentration to a lower concentration along a concentration gradient, K+ moves out of the cell. This leaves the cell potential difference at below -85mV. Finally the resting conditions are re-established with the closing of Na+ and K+ channels. The sodium-potassium exchange pump moves Na+ out and K+ in resulting in the potential difference returning to -85mV.

MT

Related Biology A Level answers

All answers ▸

What are the key principles of evolution?


Some substances can cross the cell-surface membrane of a cell by simple diffusion through the phospholipid bilayer. Describe other ways by which substances cross this membrane.


Describe the part played by each of the organelles involved in the production and secretion of the enzymes. (10)


What are the levels of protein structure?