How are action potentials transmitted across synapses using neurotransmitters such as acetylecholine?

Action potential causes depolarisation of the pre-synaptic membrane. Opens voltage gated Ca2+ and Ca2+ floods in to the pre-synaptic knob. Ca2+ binds vesicles containing acetylcholine to microtubules. These vesicles then migrate to the cell membrane and fuse with it, causing exocytosis of acetylcholine. Acetylcholine then diffuses across the synapse and binds with ligand gated Na+ receptors/ channels.These channels open allowing an influx Na+ which causes rapid depolarisation of the post-synptic membrane and generation of an action potential.The acetylcholine bound to receptors and remaining in the synapse is broken down by acetylcholinesterase to prevent overstimulation of the post-synaptic neurone. This is then reabsorbed by the pre-synaptic neurone and remade into acetylcholine.

QH
Answered by Quinn H. Biology tutor

2622 Views

See similar Biology A Level tutors

Related Biology A Level answers

All answers ▸

Cells go through a series of stages in order to replicate themselves, called mitosis. Briefly describe each stage of mitosis. (8)


How does the process of eutrophication work?


How did Meselson and Stahl provide evidence for semi-conservative replication?


How does an endotherm respond to a decrease in external temperature?


We're here to help

contact us iconContact ustelephone icon+44 (0) 203 773 6020
Facebook logoInstagram logoLinkedIn logo

MyTutor is part of the IXL family of brands:

© 2026 by IXL Learning