Suggest the effect on beta cells of respiration being inhibited

The overall effect on the beta cells, is that insulin secretion is inhibited. How this happens can be explained in more detail by looking at the underlying mechanism of this process within these cells. A standard beta cell has glucose uptake channels on its cell surface membrane (which are known as GLUT2 Transporters). When blood glucose levels are higher than normal, more glucose will be taken up via these channels into beta cells. The glucose is then used as the main substrate for aerobic respiration (or anaerobic respiration during intense exercise), and ATP is produced in the process. Potassium channels that are sensitive to ATP are also present on the cell surface membranes; if respiration has been inhibited, it will mean that these channels remain open. As a result, there is no membrane depolarisation (which would normally cause the opening of Voltage Gated Calcium ion channels and Calcium influx). Calcium ions stimulate the movement of insulin-containing vesicles to move towards the cell surface membrane, before they fuse with it and release insulin hormone via exocytosis.