How is tissue fluid formed?

Tissue fluid is the substance that bathes the cells in the body. It is the means by which materials are exchanged between the cell and blood as capillaries cannot reach every individual cell. Despite being formed from the blood plasma, tissue fluid has a slightly different composition; It has fewer proteins as large proteins fail to pass out of the capillary.Tissue fluid is formed at the arteriole end of the capillary where there is large hydrostatic pressure from the left ventricle of the heart. This hydrostatic pressure within the capillary is greater than the pressure in the fluid surrounding the capillaries, therefore forcing the fluid out of the capillaries. Despite blood having a lower osmotic potential that would want to draw water back into the capillaries, the hydrostatic pressure at the arteriole end of the capillary is still greater and therefore allows the fluid to be pushed out of the capillaries forming tissue fluid. Some of the tissue fluid is removed via the capillaries and the rest is removed via the lymphatic system.

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