MYTUTOR SUBJECT ANSWERS

1498 views

What is the difference between competitive and non-competitive enzyme inhibition?

The active site of an enzyme is the place on the enzyme molecule where the substrate (the substance which participates in the reaction catalysed by the enzyme) normally binds. 

Competitive inhibitors slow down enzyme action by acting at the active site - they bind to the active site of the enzyme molecule to prevent the substrate binding, so that that the reaction cannot be catalysed by the enzyme. The name "competitive" comes from the idea that the inhibitor "competes" to bind to the active site with the substrate. You can overcome the effect of a competitive inhibitor by simply adding more substrate so that the "competition" tips in favour of the substrate instead of the inhibitor.

Non-competitive inhibitors act at a site other than the active site on the enzyme molecule, so they don't actually "compete" with the substrate to bind to the active site. They act by changing the shape of an enzyme molecule once they bind to it, which also changes the shape of the active site. So, the substrate cannot bind to the active site anymore. You cannot overcome the effect of a non-competitive inhibitor by adding more substrate - the shape of the enzyme is changed permanently and the substrate will not bind to the active site no matter how much is present.

Krithi R. Mentoring -Medical School Preparation- tutor, Uni Admission...

2 years ago

Answered by Krithi, an A Level Biology tutor with MyTutor


Still stuck? Get one-to-one help from a personally interviewed subject specialist

166 SUBJECT SPECIALISTS

£24 /hr

Runzhi C.

Degree: Medicine (Bachelors) - Imperial College London University

Subjects offered:Biology, Maths+ 3 more

Biology
Maths
Chemistry
-Personal Statements-
-Medical School Preparation-

“Hi there, I am a first year medical student at Imperial College London and I have lived in the UK all my life. I enjoy studying medicine because it encompasses both scientific knowledge and social aspects. I am relatively new to tutor...”

£22 /hr

Josh M.

Degree: Biological Natural Sciences (Bachelors) - Cambridge University

Subjects offered:Biology, Physics+ 3 more

Biology
Physics
Maths
Chemistry
-Oxbridge Preparation-

“Who am I? I'm currently studying Natural Sciences in my third year at Cambridge University, with a focus on Neuroscience. Science is my passion, I've loved it at every level I've studied it, and a desire to pass on my passion is part ...”

£20 /hr

Susanna C.

Degree: Dentistry (Bachelors) - Newcastle University

Subjects offered:Biology, Maths+ 4 more

Biology
Maths
Chemistry
.UKCAT.
-Personal Statements-
-Medical School Preparation-

“Fun, hardworking Dental student from Newcastle University with previous mentoring experience. ”

MyTutor guarantee

About the author

Krithi R.

Currently unavailable: until 29/05/2016

Degree: Medicine (Bachelors) - Oxford, St Anne's College University

Subjects offered:Biology, Maths+ 5 more

Biology
Maths
Chemistry
.UKCAT.
.BMAT (BioMedical Admissions)
-Personal Statements-
-Medical School Preparation-

“Medical student at Oxford University, ready to offer practical advice and strategies to help you feel more confident with your subjects and university applications!”

You may also like...

Posts by Krithi

What extracurriculars should i do to get into medical school?

What is the difference between competitive and non-competitive enzyme inhibition?

Other A Level Biology questions

Why may a rise in testosterone above normal cause a subsequent decrease in the hormone?

Why is sickle cell disease most common among people living in tropical regions, and their descendants?

Discuss the products of glycolysis?

Explain how DNA is converted into protein in eukaryotes.

View A Level Biology tutors

We use cookies to improve your site experience. By continuing to use this website, we'll assume that you're OK with this. Dismiss

mtw:mercury1:status:ok