How can donepezil improve communication between nerve cells?

Donepezil is an inhibitor of the enzyme acetylcholinesterase.
Acetylcholine is a neurotransmitter that diffuses across synapses, binds to the acetylcholine receptor and causes sodium ion channels to open. Influx of sodium ions into the neurone causes a new nerve impulse to be released.In normal cells, acetylcholinesterase breaks down acetylcholine to end the signal.
In diseased cells, there are problems with communication between neurones. Because Donepezil inhibits acetylcholinesterase, less acetylcholine is broken down, so more acetylcholine is available to bind to receptors, meaning more sodium ions enter neurons to reach the threshold for an action potential. 

SW
Answered by Sarah W. Biology tutor

5953 Views

See similar Biology A Level tutors

Related Biology A Level answers

All answers ▸

Please could you explain Oxidative Phosphorylation?


What is the difference between Tumour supressor genes and Oncogenes?


Compare and contrast the features of eukaryotic DNA and RNA


Give two similarities and two differences between the structure of starch and cellulose polysaccharides (4 marks).


We're here to help

contact us iconContact ustelephone icon+44 (0) 203 773 6020
Facebook logoInstagram logoLinkedIn logo

MyTutor is part of the IXL family of brands:

© 2026 by IXL Learning