How can donepezil improve communication between nerve cells?

Donepezil is an inhibitor of the enzyme acetylcholinesterase.
Acetylcholine is a neurotransmitter that diffuses across synapses, binds to the acetylcholine receptor and causes sodium ion channels to open. Influx of sodium ions into the neurone causes a new nerve impulse to be released.In normal cells, acetylcholinesterase breaks down acetylcholine to end the signal.
In diseased cells, there are problems with communication between neurones. Because Donepezil inhibits acetylcholinesterase, less acetylcholine is broken down, so more acetylcholine is available to bind to receptors, meaning more sodium ions enter neurons to reach the threshold for an action potential. 

SW
Answered by Sarah W. Biology tutor

6064 Views

See similar Biology A Level tutors

Related Biology A Level answers

All answers ▸

Explain the role of the pancreas in controlling blood glucose levels when they are too high.


What is the key difference between the rough endoplasmic reticulum (RER), and smooth endoplasmic reticulum (SER)?


Explain the process of synaptic transmission


How do vaccinations work? Relating to humoral immunity and the secondary immune response.


We're here to help

contact us iconContact ustelephone icon+44 (0) 203 773 6020
Facebook logoInstagram logoLinkedIn logo

MyTutor is part of the IXL family of brands:

© 2026 by IXL Learning