How can donepezil improve communication between nerve cells?

Donepezil is an inhibitor of the enzyme acetylcholinesterase.
Acetylcholine is a neurotransmitter that diffuses across synapses, binds to the acetylcholine receptor and causes sodium ion channels to open. Influx of sodium ions into the neurone causes a new nerve impulse to be released.In normal cells, acetylcholinesterase breaks down acetylcholine to end the signal.
In diseased cells, there are problems with communication between neurones. Because Donepezil inhibits acetylcholinesterase, less acetylcholine is broken down, so more acetylcholine is available to bind to receptors, meaning more sodium ions enter neurons to reach the threshold for an action potential. 

SW

Related Biology A Level answers

All answers ▸

Describe and explain the role of inspiratory and expiratory muscles during normal breathing


How does gel electrophoresis seperate DNA?


Excessive dopamine causes schizophrenia. A drug used to treat schizophrenia binds to dopamine receptors in synapses. This binding does not lead to Action potentials. How can the drug used to treat schizophrenia bind to the same receptor as dopamine?


What is neurotransmission and how does a chemical synapses work?