Draw a graph on the effect of an increase in temperature on the rate of an enzyme controlled reaction. Explain the shape of the curve and suggest why the temperature of a mammal is maintained just below the optimum temperature.

As kinetic energy increases, enzyme and substrate molecules collide with more frequency allowing more enzyme substrate complexes to be formed. With increasing temperature, the tertiary structure of the protein is affected and hydrogen bonds break down; the shape of the active site is destroyed and denaturation occurs.  In mammals the default temperature is sub-optimal to prevent enzymes from being denatured and active sites to be damaged; some proteins would need to be replaced.