MYTUTOR SUBJECT ANSWERS

389 views

Outline how cystic fibrosis leads to recurrent lung infecions

   Cystic Fibrosis is a genetic condition that results from defective chloride ion channels. Normally a protein known as the “Cystic Fibrosis Transmembrane conductance Regulator” (CFTR) transports chloride ions across the cell membrane and out of the cell. This movement of Cl- ions out of the cell causes Sodium ions to also move out of the cell due to the electrostatic attractions between the Cl- and Na+ ions. The increased levels of Na+ and Cl- outside of the cell mean that the fluid outside the cell has a higher concentration of solute (IE there is a higher concentration of water molecules on the inside of the cell.) This causes water to move by osmosis out of the cell. In the cells lining the airways, These Chloride ion channels help to pump chloride and therefore sodium and water out of the cell into the surrounding mucus (which is also produced by the cells lining the airways.) This osmotic movement of water makes the mucous more watery and less viscous. In Cystic Fibrosis a mutation in the genes coding for the CFTR protein means that the ion channel is defective and cannot pump chloride ions out of the cell. This means that sodium and therefore water cannot be added to the extracellular mucus lining the airways making it very thick and sticky. This excessively viscous mucous damages the cilia (small hairs) lining the airways. The cilia cannot properly clear mucous (which contains trapped pathogens) from the airways, meaning that those pathogens linger in the airways and are more likely to enter the respiratory tract and lungs. This results in recurrent chest infections.

Vinayak N. A Level Biology tutor, GCSE Biology tutor, Mentoring -Medi...

10 months ago

Answered by Vinayak, an A Level Biology tutor with MyTutor


Still stuck? Get one-to-one help from a personally interviewed subject specialist

230 SUBJECT SPECIALISTS

£24 /hr

Harriet L.

Degree: Bachelor of Veterinary Medicine (Bachelors) - Royal Veterinary College University

Subjects offered:Biology, Science+ 2 more

Biology
Science
Maths
-Personal Statements-

“I'm studying Veterinary Medicine at the Royal Veterinary College and doing an intercalated BSc in neuroscience at King's.”

£22 /hr

Christine M.

Degree: Medicine (Other) - University College London University

Subjects offered:Biology, Physics+ 5 more

Biology
Physics
Chemistry
.UKCAT.
.BMAT (BioMedical Admissions)
-Personal Statements-
-Medical School Preparation-

“Enthusiastic medical student availible to tutor students on the medical schools admissions process and GCSE science”

£30 /hr

Anh-Duong V.

Degree: Medicine (Bachelors) - Bristol University

Subjects offered:Biology, Science+ 4 more

Biology
Science
Extended Project Qualification
Chemistry
-Personal Statements-
-Medical School Preparation-

“I’m AD, a medical student at Bristol and I offer Biology, Chemistry and personal statement tutoring!”

About the author

Vinayak N.

Currently unavailable: for regular students

Degree: medicine (Bachelors) - Nottingham University

Subjects offered:Biology, Maths+ 2 more

Biology
Maths
Chemistry
-Medical School Preparation-

“ABOUT ME AND MY TEACHING STYLE     I am a final year medical student at Nottingham and I like to take a friendly relaxed approach to both being a student and a teacher. I am easy going and very passionate about both teaching and scien...”

MyTutor guarantee

|  1 completed tutorial

You may also like...

Other A Level Biology questions

How does an electrical impulse travel the gap between two nerves?

How do enzyme controlled reactions work?

How does the human body regulate its blood glucose levels?

What occurs during an action potential in a neuron?

View A Level Biology tutors

We use cookies to improve your site experience. By continuing to use this website, we'll assume that you're OK with this. Dismiss

mtw:mercury1:status:ok