How does oxidative phosphorylation work in respiration

Reduced NAD/FAD from previous stages of respiration (glycolysis, link reaction, Krebs cycle) relocate from the mitochondrial matrix to the inner mitochondrial membrane. At this point they are oxidised, losing their extra electron to proteins (cytochrome proteins) which are embedded in the inner membrane of the mitochondria. The NAD/FAD are then shuttled back to the mitochondrial matrix where they can be reused in earlier stages of respiration. The electron that was lost then passes down a series of cytochrome proteins (known as the ELECTRON TRANSPORT CHAIN or ETC), and as it does releases energy which is used to transport free H+ ions from the mitochondrial matrix into the inter membrane space. This creates an H+ concentration gradient across the inner mitochondrial membrane, with a higher concentration of H+ in the inter membrane space than in the matrix. H+ ions then move down this concentration gradient and back into the matrix through ATP synthase. By moving through this protein, it is activated and can combine ADP and an inorganic phosphate molecule to form ATP. Finally, once the electron reaches the end of the ETC and combines with oxygen, reducing it. This oxygen can then combine with H+, which has moved into the matrix, and form water.

Answered by Fionn M. Biology tutor

2504 Views

See similar Biology A Level tutors

Related Biology A Level answers

All answers ▸

Draw a graph on the effect of an increase in temperature on the rate of an enzyme controlled reaction. Explain the shape of the curve and suggest why the temperature of a mammal is maintained just below the optimum temperature.


Explain diffusion?


How are nerve cells adapted to their function?


Explain how a rise in blood pressure results in a decrease in the rate of heartbeat.


We're here to help

contact us iconContact usWhatsapp logoMessage us on Whatsapptelephone icon+44 (0) 203 773 6020
Facebook logoInstagram logoLinkedIn logo

© MyTutorWeb Ltd 2013–2024

Terms & Conditions|Privacy Policy